Episodes
Host Dave Asprey breaks down five emerging health and longevity stories. He covers a mouse study on plasmalogens from sea squirts improving brain aging, the Apple Watch Series 12's new health features including Health Age and HRV tracking, the FDA's move to accelerate botanical drug development, a long-term study linking adolescent cannabis dependence to IQ decline, and research on pterostilbene from blueberries helping muscle cells burn fat. Asprey separates promising mechanisms from premature hype, emphasizing evidence quality and biological context.
Dr. Karan Rajan, a gut surgeon and Chief Science Officer at Throne, breaks down why fibermaxxing can backfire without the right mix of fermentable fibers, how protein absorption limits work, and why the sodium-to-potassium ratio matters more than sodium alone. He explains the migrating motor complex, what your poop reveals about liver and metabolic health, and the role of the estrobolome and testobolome in hormone balance. The conversation also touches on fasting, saturated fat, and how AI is starting to personalize gut health tracking.
Dave Asprey outlines his core strategy for rapid weight loss built around overcoming insulin resistance — what he calls the primary metabolic block that locks fat cells shut. The episode details three foundational rules: eliminating processed foods, incorporating fasting to lower insulin, and redesigning your kitchen environment to outsource willpower. Asprey distinguishes between real hunger and conditioned cravings, explaining how snacking keeps insulin chronically elevated and stalls fat loss.
A rapid-fire research roundup covering five biohacking topics. Dave Asprey separates the viral raw garlic trend's real biochemistry from its overblown claims, explains why a one-month HEPA filtration study showing cognitive improvement matters, and connects new egg yolk peptide research to his case for whole eggs. He also contrasts deliberate heat stress with the lasting cardiovascular damage from uncontrolled heat stroke, and interprets a large observational study linking long-term melatonin use to elevated heart failure risk.
Dave Asprey and Jenny McCarthy Wahlberg discuss her son's autism recovery after a vaccine reaction, sharing the biohacking protocol that reversed his symptoms through candida detox, charcoal binders, and diet changes. They explore the role of mitochondrial dysfunction, mold toxicity, and neuroinflammation in autism, then shift to adult longevity strategies including HRT, peptides, nootropics like modafinil, and cyclical ketosis. The conversation covers functional medicine tools such as electrolyte balancing, blackout darkness for sleep, and why Jenny trusts krill oil over fish oil. This episode offers practical biohacking insights for brain optimization and disease reversal.
Dave Asprey challenges the conventional longevity drug list, explaining why metformin, rapamycin, and statins fail the human data. Metformin may blunt exercise adaptation and deplete vitamin B12. Rapamycin's mouse-study promise collapsed in the 2025 PEARL trial. Statins come with a steep harm-to-benefit ratio and drain mitochondrial CoQ10. Asprey then walks through a 'yes list' of four repurposed pharmaceuticals — tadalafil, SGLT2 inhibitors, acarbose, and low-dose naltrexone — and explains how each supports metabolism, mitochondrial function, and immune regulation.
After overcoming his own brain fog, the host breaks down seven science-backed compounds—from sulbutiamine to ACE 167—that boost brain energy, communication, muscle repair, and hormone production for sharper focus and long-term performance.
Dave Asprey interviews Hal Elrod, author of The Miracle Morning, about his powerful morning routine and the life-altering experiences that shaped it. Hal shares the updated SAVERS framework—six practices that can transform your day. He recounts his near-death car accident and rare cancer diagnosis, explaining how these traumas became catalysts for growth and a deeper sense of purpose. The conversation also explores redefining what it means to help others, customizing your morning to fit your life, and practical tips for sleep and relationships.
Jonny Miller, founder of Nervous System Mastery and host of Inner Frontier, joins Dave Asprey to break down the three skills behind nervous system mastery: interoception, self-regulation, and emotional fluidity. They discuss the half-life of reactivity, a measurable way to track emotional recovery, and why free diving serves as high-stakes meditation. The conversation covers grief, co-regulation, and the cost of incongruence, including Dave’s $100 million lesson from a business betrayal. Jonny shares how community speeds healing and introduces his Breath Buddy device for teaching kids nervous system regulation.
Jim Kwik, brain coach and memory expert, sits down with Dave Asprey to discuss the dangers of outsourcing your thinking to AI. They examine an MIT study showing that using AI for writing and thinking degrades memory and comprehension, and introduce concepts like digital dementia and cognitive sovereignty. The conversation covers how to use AI as a brain optimization tool rather than a crutch, the MEDS Rx framework for brain health (meditation, exercise, diet, sleep, relationships), and why the first moments after waking set the tone for your entire day.
Dave Asprey explores NAD+ as the central molecule driving aging, explaining why levels decline with age and how the imbalance between production and destruction leads to fatigue, brain fog, and slow recovery. He outlines the early signs of depletion and a step-by-step protocol—diet, fasting, exercise (REHIT), and supplementation—to restore NAD+ and combat aging at the cellular level.
Dave Asprey speaks with Gurudev Sri Sri Ravi Shankar, founder of the Art of Living, about breathwork, consciousness, and the intersection of science and spirituality. They discuss the origins of Sudarshan Kriya, a breathing technique practiced by millions, and its effects on mental health and peace. The conversation covers curiosity, non-dual consciousness, intuition, and the growing scientific support for meditation. Gurudev shares insights on transcending fear and using ancient practices to address modern challenges like PTSD and dating app culture.
Quantum scientist Patrick Coles joins Dave Asprey to present his Toxin Sequestration Theory, which proposes that cancer tumors are deliberate storage vaults the body builds to isolate toxins, heavy metals, seed oils, mold, and excess glucose away from healthy tissue and mitochondria. The conversation contrasts this framework with the mainstream genetic theory of cancer and the metabolic theory popularized by Thomas Seyfried. Asprey and Coles explore why chemotherapy may behave as a tissue-damaging toxin, and they discuss oxalates, deuterium, linoleic acid, circadian biology, and detox protocols involving binders. They also connect sleep optimization, fasting, ketosis, and carnivore nutrition to the body's detox hierarchy. The episode is aimed at listeners interested in longevity, anti-aging, and human performance.
Dave Asprey and Gabby Reece sit down for a double interview exploring hormone optimization after 50, mitochondrial function, and longevity protocols. Gabby shares how weekly testosterone injections and a compounded vasodilation cream—"scream cream"—resolved a heart arrhythmia that doctors initially misdiagnosed as a cardiac issue. Dave explains his theory that autism can bring cognitive superpowers once physical symptoms are addressed, outlines his personal cancer-prevention protocol involving antifungal agents and infrared light, and details the peptides he uses for mitochondrial renewal including SS-31 and Russian bioregulators. The conversation also covers cyclical ketosis, why Dave avoids GLP-1 drugs despite their longevity potential, and what both have learned about surrender versus control in building a life around high performance.
In this solo episode, Dave Asprey explains that chronic fatigue and brain fog are not inevitable consequences of aging but rather symptoms of damaged mitochondria when a cellular cleanup process called mitophagy shuts down. He walks through how stress, declining NAD+, and other factors impair mitophagy, and outlines practical strategies to reactivate it, including fasting, REHIT exercise, cold exposure, and targeted supplements. The episode provides a concise overview of mitochondrial health as a key anti-aging switch.
Dave Asprey reviews recent health and longevity news, covering an FDA-cleared inhaled Alzheimer's trial, a breakthrough in adult brain self-repair, a wool-based alternative to collagen for bone regeneration, oral GLP-1 weight loss data, the limitations of standard exercise guidelines for heart protection, and new clarity on IV vitamin C's anti-cancer mechanism. He closes by reflecting on Linus Pauling's fifty-year vindication and what it teaches about revisiting abandoned ideas.
Dave Asprey goes solo for a masterclass on piracetam and the wider racetam family, the original nootropics that launched the smart drug movement. He explains how these compounds work and who stands to benefit from them. The episode covers proper dosing and walks through the safety and regulatory landscape around racetams. It is framed as a foundational overview of the compounds that started modern cognitive enhancement.
Dr. Steven Greer, a retired emergency physician and UFO researcher, joins Dave Asprey to argue that extraterrestrial intelligence is already interacting with Earth. He claims that suppressed free-energy technology could eliminate global poverty. He warns that humanity's future depends on truthful disclosure of these realities, not a weaponized one.
Oxidative stress is a primary driver of skin aging, and the body’s master antioxidant, glutathione, protects collagen more effectively than applying collagen itself. This episode examines how a new delivery system, RO-GSH, finally enables topical glutathione to penetrate the skin. It highlights a study showing that 300mg of this formulation visibly reduced wrinkles and improved skin tone in just one week.
This roundup covers a drug-repurposing screen that searched existing medications for longevity benefits, the protein restriction mechanism through FGF21, a new injectable derived from cadaver tissue for skin rejuvenation, new evidence that arts engagement slows biological aging, and a systematic review of 41 studies testing biohacking interventions against epigenetic clocks.
Regena 'Mama Gina' joins Dave Asprey to discuss how embracing pleasure, embodiment, and reverent surrender can heal trauma, restore intuition, and unlock the divine feminine. The conversation explores practical pathways to deep physical and spiritual connection available to both women and men.
Dr. Vivek Lal explains the gut-lung axis he discovered, detailing how gut bacteria regulate lung inflammation through the MMP-9 pathway. He discusses why the lung microbiome may be the next major frontier in longevity and respiratory health. Dave Asprey shares his personal supplement stack of 150 pills a day and highlights which one he relies on most.
Dave Asprey explains how aging is driven by declining glutathione levels and the resulting mitochondrial damage. He makes the case for topical glutathione delivery—specifically the Glutaryl product—as a practical way to support cellular repair and counteract oxidative stress. The episode covers why oral glutathione is often ineffective and how transdermal application may be a more direct anti-aging strategy.
In this rapid-fire episode, Dave Asprey covers five recent health research findings. Topics include Viagra's potential to fight cancer, how watching TV could accelerate brain aging in men, and why living in a hot neighborhood might speed up biological aging. He also discusses superbugs emerging from industrial chicken farming and a surprising technique using CO2 to activate the brain's waste-clearance system. Short but packed with actionable science.
Ashley Grace, executive at Igniton, joins Dave Asprey to discuss the company's proprietary subatomic particles called ignitons. She explains how Igniton's $18 million private lab charges supplements with these particles to enhance memory, sleep, and longevity. The conversation explores the science behind the process and the claimed benefits of igniton-charged supplements.
Urologist Alex Tatem discusses evidence-based methods for penis enlargement, including fillers, traction devices, and surgery, revealing what actually works and what doesn't. The conversation also covers the psychological impact of penis size on men's confidence, the potential of peptides like PT-141, BPC-157, and SS-31 for sexual and overall health, and the role of testosterone replacement therapy. The episode highlights the ongoing regulatory battles over compounding pharmacy access that threaten patient access to these treatments.
In this solo episode, Dave Asprey explains the concept of "sleep fasting" — avoiding food within three hours of bedtime. He argues that eating too close to sleep keeps the digestive system active, which hinders the natural cortisol dip necessary for deep cellular repair. This simple three-hour pre-bed food cutoff can significantly improve sleep quality, energy, and overall recovery.
Dave Asprey breaks down the latest health research and news in a rapid-fire format. He discusses new findings on how artificial sweeteners and muscle fat impact cardiovascular health, a new cholesterol pill entering the market, a recent lettuce-borne outbreak, the gut-brain connection to anxiety, and the surprising truth about the banana-blueberry smoothie. Each topic is paired with practical takeaways and predictions for future health trends.
Dave Asprey talks with microbiologist Kiran Krishnan about the role of gut endotoxins in chronic disease and how spore-based probiotics, like Just Thrive, can neutralize these toxins to improve hormone health, body composition, bone density, and longevity.
Dr. Sean O'Mara explains the difference between visceral and subcutaneous fat, why visible abs don't guarantee metabolic health, how MRI scans detect hidden disease, and the fasting and microbiome strategies that can change your fat distribution.
Dave Asprey breaks down how to assemble a complete biohacking protocol for less than $200. He walks through specific, low-cost interventions—red light bulbs, blackout curtains, blue-light blocking glasses, creatine, MCT oil, spermidine, and magnesium—that collectively improve sleep, brain energy, and cellular repair. The episode is a practical guide for those starting their longevity journey without expensive equipment.
Shawn Stevenson discusses the science behind family meals and their impact on childhood obesity and overall health. He shares research on the minimum frequency of shared meals and explains why communal eating is a powerful yet overlooked longevity habit in the modern world.
Dr. Nayan Patel joins Dave Asprey to discuss glutathione, the body's master antioxidant. He explains why common supplementation methods—oral capsules, liposomal liquids, and IV drips—fail to deliver glutathione to the cells where it's needed. Patel then shares his breakthrough in transdermal glutathione delivery, which finally overcomes these barriers. The conversation covers the science behind glutathione's role in detoxification, aging, and cellular health, and why proper delivery is the key to unlocking its benefits.
Dr. Peter McCullough joins The Human Upgrade to discuss his views on the spike protein, its origins in 2015 gain-of-function research, and why it can persist in the body for over three years after vaccination. He outlines a detox protocol to clear remaining spike proteins and addresses the suppression of early COVID treatments. McCullough also details the changes he would implement at HHS to refocus health policy on early treatment and vaccine safety.
This episode explores how a traditional Japanese breakfast of natto, rich in spermidine, can activate autophagy — the body's Nobel Prize-winning cellular repair process — and potentially reverse biological aging within 72 hours when supported by proper dosing, exercise, sleep, and diet. The host explains how this ancient dietary practice might be a potent anti-aging hack.
Jordan Harbinger shares the chilling story of how he talked his way out of two separate kidnappings, using psychological tactics to stay calm and de-escalate life-threatening situations. He then unpacks the practical systems behind his productivity and charisma, including a rigid calendar-blocking method, simple pain-point hacks for habit change, and a systematic approach to relationship-building that has powered his podcasting career. The episode blends high-stakes survival with actionable daily performance strategies.
Dave Asprey and Dr. David Perlmutter discuss how microglial dysfunction and chronic inflammation may be the real drivers of Alzheimer's and Parkinson's disease, challenging the long-held amyloid hypothesis. They examine emerging treatments such as GLP-1 drugs, 40 hertz light therapy, and lifestyle interventions that target brain health. The conversation explores why decades of research focused on amyloid plaques has failed to yield effective therapies, and what new approaches offer hope.
In this episode of The Human Upgrade, Dave Asprey is joined by researcher Brain Richards to discuss a light therapy first developed in 1910 that was historically suppressed. The conversation explores how specific light wavelengths can restructure water within cells, boost mitochondrial energy production, and potentially counteract the damage caused by ubiquitous blue light and electromagnetic fields. Richards shares his insights into the science behind this approach and how it might be used as a therapeutic tool.
Dave Asprey reviews several legal focus-enhancing compounds—caffeine with L-theanine, adaptogens, MCT oil, methylene blue, and creatine—and explains how each supports brain energy and mental clarity. He shares a stacking protocol designed to deliver sustained focus without the crashes or jitters typical of stimulants alone.
In this short roundup, Dave Asprey covers recent health news: new research on gut-derived acetate and its impact on brain health, the side effects of GLP-1 agonists on taste and smell, the prevalence of the cat parasite Toxoplasma gondii, exercise’s strong mental health benefits, and individual differences in how people process plant phytonutrients. He also touches on produce pesticide safety guides and the acquisition of Thorne by Unilever. The episode ends with a call to track your own biomarkers rather than passively consuming health headlines.
Dave Asprey interviews Ben Azadi, founder of Keto Kamp, about his 90-day strict carnivore experiment. They discuss surprising gut improvements without fiber, the benefits of cyclical ketosis, electrolyte strategies, and using creatine for sleep and cognitive performance. Ben shares practical tips from his own biohacking experiments, and both hosts reflect on building health platforms in the face of online criticism.
Dr. Anna Cabeca, triple board-certified OBGYN and oxytocin researcher, joins Dave to discuss how optimizing oxytocin—along with estrogen and FSH—can rejuvenate brain health, relationships, and longevity. She critiques the conventional medicine approach to female hormones and outlines natural strategies for boosting these crucial signals.
Dave Asprey explains the science behind NAD+ as a critical anti-aging molecule supported by Nobel Prize-winning research. He details how age-related declines in NAD+ contribute to fatigue, brain fog, and degeneration, and outlines a comprehensive protocol to restore NAD+ levels, including diet, polyphenols, fasting, REHIT exercise, and NMN/NR supplementation.
Dave Asprey breaks down the latest biohacking research, questioning whether fish oil actually protects the brain, exploring anti-aging lessons from butterflies, uncovering an ancient brain mechanism that governs focus, and identifying the dietary patterns that best support long-term cognitive health. He examines recent evidence that challenges the long-held belief that fish oil is a no-brainer for brain protection, and instead presents a more nuanced picture of its efficacy. The episode also covers surprising findings from butterfly biology that could inform human longevity strategies, and practical tips for improving attention by tapping into the brain’s evolutionary built-in focus switch.
Jeff Boyd, founder of MTE, explains how conventional energy drinks sabotage cortisol rhythms, sleep, and gut health. He outlines how a full-spectrum stack of adaptogens, nootropics, and prebiotics delivers clean, foundational energy without the crash.
Dr. Elie Abirached shares how his childhood war trauma led him to develop a biohacking philosophy centered on nervous system mastery and intentional living. The conversation explores the connection between early adversity and nervous system dysregulation, and how intentional biohacking practices can restore control. Abirached discusses how biohacking is not just about physical optimization but a purposeful approach to life.
This episode explains how mitophagy—the body’s natural mitochondrial cleanup system—declines due to stress, diet, and aging, and details several fast-acting ways to reactivate it, including fasting, high-intensity exercise, cold exposure, NAD+ supplementation, urolithin A, and spermidine.
In this solo episode, Dave Asprey breaks down five recent studies that challenge what you think you know about copper therapy for Alzheimer's, sugar-free diets, strength training, childhood brain development, and taurine. Each segment reveals why surface-level labels often misrepresent the underlying science. The episode runs under 12 minutes and is packed with actionable nuance.
In this episode, board-certified psychiatrist and neuroscientist Dr. Dave Rabin explores how psychedelic therapies like MDMA and ketamine are revolutionizing mental health. He explains the epigenetic mechanisms by which these substances help repair deep-seated trauma, contrasting this with conventional antidepressants that he argues often keep patients sick. Rabin makes the case that psychedelic medicine is the most important breakthrough in the history of psychiatry.
Dermatologist Dr. Michael Christopher reveals a melanoma detection gap most doctors miss, and shares the tools, habits, and skin science that can protect your skin and extend your life.
In this solo episode, Dave Asprey explains that the key to effortless focus isn't willpower but Vitamin C. He argues that the brain requires adequate Vitamin C to produce the neurotransmitters that sustain attention, and that most people's mental fatigue stems from a deficiency. He offers guidance on how to supplement correctly to activate what he calls the brain's 'deep focus switch.'
Dave Asprey runs through six health and biohacking stories, focusing on the molecular mechanisms behind each. Topics include GLP-1 drugs shifting epigenetic aging clocks, the FDA finally approving European-style sunscreen ingredients, and a DNA sugar that may regrow hair. He examines how understanding what these molecules do inside the body can unlock better health interventions.
Dave Asprey speaks with neurologist Dr. Majid Fotuhi about the treatable nature of brain fog and cognitive decline. Dr. Fotuhi explains why the brain physically shrinks due to lifestyle factors and shares his holistic program for preventing Alzheimer's and restoring brain health, drawn from 37 years of clinical experience and training at Johns Hopkins and Harvard.
Dr. William Li joins Dave to explain how food is the most powerful medicine, with research on foods that starve cancer by cutting off blood supply. He shares data from a study of 720,000 centenarians about the longevity secrets tied to vascular health. Li makes the case that maintaining healthy blood vessels is the key to living longer and better.
Dave Asprey shares the personal experiment that led to his 100-pound weight loss: replacing sugar with butter and MCT oil in his morning coffee. The simple dietary shift transformed his metabolism and sparked the global Bulletproof Coffee movement. In this short episode, he reflects on the experience that overturned conventional diet advice.
Dave Asprey covers three cutting-edge medical developments: an engineered virus that stops pancreatic cancer, a diabetes drug (likely a GLP-1 agonist) that cuts breast cancer risk, and the landmark Finnish sauna study that settles the debate on sauna benefits.
Dave Asprey talks with the founders of Mara Labs about how sulforaphane, the active compound in their BroccoLite supplement, can activate the body's detoxification pathways to help excrete microplastics, heavy metals, and other toxins. The conversation also covers sulforaphane's potential benefits for brain health, hormone balance, autism support, and longevity. The founders present BroccoLite as a superior delivery method for sulforaphane.
Dave Asprey talks with Justin Kirkland, a chemist with 30 years of peptide synthesis experience. They explore how peptides are made, how to ensure quality when buying, and alternative delivery methods like microneedle patches and nasal sprays that bypass needles. Kirkland shares his view on which peptides live up to the hype and which are overrated, and why genetic and microbiome factors make personalization key. The conversation also covers the risks of the gray market and the future of precision peptide dosing.
Dave Asprey shares his 15-year struggle with severe brain fog and how he discovered the root cause wasn't in his brain but in his feet. He explains the science linking weak calf muscles, reduced blood flow to the brain, and modern cushioned shoes that block essential sensory signals from the feet. This sensory deprivation keeps the nervous system in a survival state that tanks executive function. He outlines the barefoot walking and foot-strengthening protocols that lifted his fog and restored his mental clarity.
In this news roundup, Dave Asprey covers a range of biohacking and health stories: the inaugural Enhanced Games performance-enhancing competition, the implications of Kyle Busch's death for understanding sepsis and inflammation, a newly discovered brain protein that may regulate aging speed, emerging research linking depression to the immune system, and a genetics paper suggesting that a large portion of lifespan is determined before birth.
Dr. Andrew Salzman joins Dave Asprey to explain how a leaky gut barrier triggers a cascade of NAD depletion and systemic inflammation that accelerates aging. He outlines the mechanism and makes the case that combining creatine with targeted NAD support is key to counteracting this root cause of aging.
Dave Asprey and Dr. Jessica Peatross explore the root causes of chronic illness that mainstream medicine often overlooks. They discuss parasites, toxic mold, histamine intolerance, and cortisol dysregulation as keys to unlocking mystery symptoms. They also critique the medical system's failure on Lyme disease and regulatory capture.
This episode distills the longevity secrets of Okinawa, a Blue Zone where people reach 100 in record numbers. Host Dave Asprey breaks down five science-backed habits: mindful eating (hara hachi bu), a sense of purpose (ikigai), staying physically active, maintaining strong social bonds, and managing stress. He explains how each habit contributes to a longer, healthier life. It's a quick, actionable guide to adopting the Okinawan formula.
Dr. Patrick Porter, founder of BrainTap, joins Dave Asprey to discuss his brainwave entrainment technology. Porter claims that 40 Hz gamma flickering light can break up amyloid plaque, citing 72 peer-reviewed studies. The device also aims to reset sleep and rewire the brain for peak performance, with benefits achievable in as little as 10 minutes a day. The conversation explores how non-invasive light and sound can hack brain chemistry for better health and cognition.
Dave Asprey interviews Chris Rinsch, co-founder of Timeline Longevity, about the 18-year development of urolithin A, a postbiotic compound that triggers mitophagy and is backed by extensive clinical research. They discuss how it outperforms rapamycin in clearing damaged mitochondria and its position as one of the most validated longevity supplements. The conversation covers the science of aging at the cellular level and practical applications for healthspan.
When you hit your 40s, you start catching colds more easily, wounds take longer to heal, and you feel rundown even after a full night's sleep. Your doctor will tell you "it's just aging." They're wrong.
Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried.
Your brain is aging faster than it should, and most of the decline is self-inflicted. Neuroscientist Dr. Tommy Wood reveals the exact mechanisms driving cognitive decay, and the biohacking strategies backed by hard science that can stop it, reverse it, and future-proof your brain at any age.
You are not eating because you are hungry. You are eating because you have been trained to, and the food industry designed it that way.
I lost 100 pounds, dropped to 4.8% body fat, and my lab tests say I'm biologically in my 30s... at 50 years old. Here's everything I got wrong about weight loss for years, and what actually worked.
This week's stories: ***Virologist Self-Injects Oncolytic Virus Therapy, Achieves 4-Year Remission in Triple-Negative Breast Cancer*** A researcher facing terminal triple-negative breast cancer (28% 5-year survival rate) engineered her own measles and vesicular stomatitis viruses and self-administer
Your body already makes the most powerful wound-healing molecule on the planet, and now you can use it at home.
The government is finally catching up to what biohackers have known for decades, and the man helping lead that charge just sat down with Host Dave Asprey to talk longevity science, aging biomarkers, dietary overhaul, AI in medicine, and what a real science-first health agenda actually looks like.
My favorite creatine (discount code DAVETUBE): Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance.
This week's stories: *Bartonella Hides in Cat Scratches — and It Might Be Why You Feel Like Garbage A stealth bacterial infection transmitted by everyday cat scratches and flea dirt has been quietly linked to chronic fatigue, brain fog, and neurological symptoms for decades.
Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones.
Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried.
I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn’t come from a pharmaceutical lab. It came from NASA.
Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots.
Autism is reversible, and the science to prove it already exists.
Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy.
Try TrueDark (with my discount): I have spent 20 years and over $2 million testing my biology, and the biggest lesson I've learned is that sleep is a neurological system, not just a chemical one.
Your brain is hardware, and if the hardware is broken, no supplement stack, nootropic, or biohacking protocol in the world will get you to full capacity.
What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using?
Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is.
Try TrueDark (with my discount): I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".
This week's stories: *SNL Roasts the MAHA Movement Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience.
Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.
What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort?
Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.
This week’s stories: Smartphone App Catches What Sleep Trackers Miss A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance.
Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: Host Dave Asprey sits down with Dr.
What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level?
Block toxic light with these glasses: Think 8 hours of sleep is enough? Think again. I used to think I had a sleep issue—turns out, it was a light issue. In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery.
This week’s stories: Healthy Diets That Offset "Bad Genes" A major UK Biobank study of over 100,000 people found that following any one of five healthy dietary patterns was associated with up to 3 extra years of life — and the benefit held regardless of genetic predisposition to longevity.
Microplastics are invading your brain, blood, hormones, and fat tissue, and most people have no idea how deep the damage goes.
Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology.
What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?
This week’s stories: Sinclair’s This Is the Test: Are we about to see age reversal in humans?
Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist.
Your skin is not just a cosmetic surface. It’s a living organ that responds to signals, and the right light signal can flip your biology into repair mode.