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The Human Upgrade · September 16, 2026 · 00:55:33

Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537

Actor and Gatlan Health founder Josh Duhamel joins Dave Asprey to discuss his personal journey with hormone optimization, including why he started testosterone replacement therapy (TRT) in his early 40s and how it transformed his energy, strength, and motivation. The conversation covers the landscape of longevity tools available today, from peptides and nootropics for cognitive performance to GLP-1s and stem cells, with an emphasis on the importance of sourcing quality products and working under medical guidance. Duhamel also reflects on how becoming a father later in life has made extending his healthspan a deeply personal mission, and the discussion expands to include the role of spirituality, breathwork, and psychedelics in overall well-being.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Preview

Individualized Testosterone Optimization19:36
Josh Duhamel shares his experience starting TRT in his early 40s and explains how tracking and optimizing his hormones led to transformative improvements in energy, strength, and motivation.
Leveraging Nootropics for Cognitive Longevity
The conversation highlights Duhamel's past struggles with memory, such as forgetting lines, and his subsequent interest in nootropics, alongside Dave Asprey's experiences with compounds like Modafinil and Aniracetam for cognitive enhancement.

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