NAD Decline Drives Aging and Cognitive Decline
research · NAD+ metabolism and its roles in cellular processes during ageing (2016)
NAD is essential for energy metabolism and cellular repair, and its levels decline with age, contributing to many hallmarks of aging.
Core Concepts
The Problem
NAD levels drop by up to 50% by middle age, impairing energy production, DNA repair, and immune function.
The Claim
Restoring NAD levels can improve mitochondrial function, cognitive performance, and overall healthspan.
Key Evidence
- •Multiple studies show NAD levels decline with age in humans and animals.
- •Inflammation increases CD38 activity, which degrades NAD and accelerates decline.
- •Precursor supplementation (NMN, NR) has been shown to raise NAD and improve health markers in animals.
Practical Implication
Addressing NAD decline could be a key target for anti-aging interventions, potentially delaying cognitive decline and metabolic dysfunction.
Nuance & Limits
Not all NAD-boosting strategies are equivalent, and long-term human data is still limited. Chronic inflammation must be addressed to sustain NAD levels.
Source Material
Citation Density
High
Gaps
- ⚠ Long-term human safety and efficacy of NAD precursors not fully established.
- ⚠ Individual variations in response to supplementation.
Discuss Further
Open this concept in an AI assistant for deeper discussion, critique, or exploration.