Lowering Blood Sugar Without Weight Loss | Dr Nicola Guess

Can you meaningfully improve type 2 diabetes without losing weight? Dr Nicola Guess, a registered dietitian and Senior Research Fellow at the University of Oxford, presents evidence that a higher-protein, lower-carbohydrate diet can lower post-meal glucose more than medication, without weight loss. The discussion covers why glucose only causes direct harm at diabetic levels, how protein wakes up “sleepy” beta cells, and what overfeeding trials reveal about insulin and obesity. They also address fruit fear, insulin-first theories of obesity, GLP-1s and muscle loss, and metabolic health during menopause, PCOS, and shift work. This episode is a clear-eyed guide to metabolic health without the hype.