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The Peter Attia Drive #334 · February 3, 2025 · 170m
Cardiovascular disease: apoB, cholesterol, and the number one killer
Tom Dayspring on why standard cholesterol testing is inadequate. ApoB — the number of atherogenic particles, not the cholesterol they carry — is the causal agent. Every additional year of elevated apoB accumulates irreversible arterial damage.
This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.
Highlights
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apoB is the causal agent of atherosclerosis — not LDL cholesterol
Dayspring: the cholesterol hypothesis got it half right. It's not the cholesterol inside the particle that matters — it's the particle itself (measured by apoB). You can have normal LDL-C and dangerously high apoB, or high LDL-C and acceptable apoB.Was this useful?