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The Peter Attia Drive #303 · May 27, 2024 · 130m
Klotho: a breakthrough in Alzheimer's prevention
Dena Dubal on klotho — a longevity factor that protects cognitive function. Klotho levels decline with age and predict cognitive decline. A single injection of klotho improved cognition in aging mice. Exercise increases klotho; stress decreases it.
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Canon
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Dubal: klotho is a hormone that declines with age and is inversely correlated with cognitive decline, Alzheimer's risk, and metabolic dysfunction. It sits at the intersection of metabolism and neurodegeneration — supporting the 'Type 3 Diabetes' hypothesis.
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