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Dave Asprey talks with Sarah Kennedy about Amarasate, a hops-derived compound that activates bitter receptors in the gut to stimulate natural GLP-1, CCK, and PYY production. Clinical trials show an 18% reduction in calorie intake, and a six-month study found 5.5% body weight loss with three times more visceral fat reduction and no muscle loss. They discuss how this approach makes intermittent fasting easier by reducing hunger without willpower, and why overeating is driven by hormonal signals, not a lack of discipline.
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