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The Human Upgrade · October 29, 2026 · 51:32

The No-Brainer Solution To Stop Overeating

Dave Asprey talks with Sarah Kennedy about Amarasate, a hops-derived compound that activates bitter receptors in the gut to stimulate natural GLP-1, CCK, and PYY production. Clinical trials show an 18% reduction in calorie intake, and a six-month study found 5.5% body weight loss with three times more visceral fat reduction and no muscle loss. They discuss how this approach makes intermittent fasting easier by reducing hunger without willpower, and why overeating is driven by hormonal signals, not a lack of discipline.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

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Bitter taste receptors in the gut stimulate natural satiety hormones03:06
Amarasate from New Zealand hops activates bitter taste receptors in the gut, triggering the release of appetite-regulating hormones GLP-1, CCK, and PYY.
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18% reduction in calorie intake10:15
Clinical research on Amarasate found an average 18% reduction in calorie intake after consumption.

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