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Huberman Lab #253 · November 3, 2025 · 2h 5m
Using Existing Drugs in New Ways to Treat & Cure Diseases of Brain & Body
Penn physician David Fajgenbaum on drug repurposing — the idea that existing, approved medications may treat conditions they weren't designed for. He found his own cure this way after being given weeks to live with Castleman disease.
This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.
Highlights
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Existing drugs may already treat diseases we haven't tested them for
Fajgenbaum: there are ~20,000 approved drugs but most have only been tested for their original indication. Systematic drug repurposing could find treatments for diseases that have none — at a fraction of the cost of new drug development.References
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Chasing My Cure — David Fajgenbaum — His story of finding his own treatment
Misc
✧Fajgenbaum nearly died five times before finding his treatment — he was a medical student at the time
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