Dr. Rhonda Patrick interviews ketosis researcher Dr. Dominic D'Agostino about the science behind ketogenic diets, from therapeutic applications to daily lifestyle. They cover how to design a well-formulated keto diet, the use of exogenous ketones for brain health and performance, optimal blood ketone targets, and the diet's effects on muscle preservation, neurodegenerative disease, and more. D'Agostino shares practical insights from over a decade of personal experimentation and research.
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D'Agostino discusses the potential of the ketogenic diet to provide an alternative fuel for the brain in Alzheimer's disease, bypassing impaired glucose metabolism.
The Ketogenic Diet Is a Spectrum, Not a Monolith08:42
D'Agostino distinguishes between different forms of ketogenic diets, from the classic 4:1 ratio used for epilepsy to the more flexible lifestyle keto, each with distinct therapeutic and practical applications.
Exogenous Ketones Uncouple Ketosis from Strict Diet33:40
Exogenous ketones, such as ketone esters and salts, can elevate blood ketone levels independently of dietary restriction, potentially delivering cognitive and neuroprotective benefits even when consuming carbohydrates.
Optimal Ketone Range for Cognitive and Performance Benefits55:48
D'Agostino shares his recommended blood concentration range for beta-hydroxybutyrate to achieve cognitive clarity and anti-catabolic effects without unnecessary extremes.
Ketogenic Diet Preserves Muscle Mass During Fat Loss01:13:31
Contrary to the myth that low-carb diets cause muscle wasting, D'Agostino explains that a well-designed ketogenic diet has anti-catabolic effects, helping to spare muscle protein.