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Feel Better, Live More · June 16, 2026 · 1h 41m

The 5 Most Important Biomarkers That Influence Your Health & How To Live Better For Longer with Dr Florence Comite #666

Dr Florence Comite, a Yale and NIH-trained endocrinologist, joins Dr Rangan Chatterjee to discuss why our health trajectory is far from fixed. Drawing on 30 years of clinical experience and her book 'Invincible', she explains how decline is not inevitable but detectable—and therefore reversible. The conversation covers five critical blood biomarkers that standard medicine overlooks, including fasting insulin and free testosterone, and how continuous glucose monitors can personalise nutrition. Her core message is that by tuning into our body's early signals, we can make targeted changes to improve how we age.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Canon

Dr Comite’s work is built on the idea that the physical and cognitive declines we associate with ageing are not preordained—they can be spotted early and reversed through targeted interventions.

Highlights

The Five Key Biomarkers Every Adult Should Know About
Florence Comite highlights five specific blood tests that offer an early-warning system for metabolic and hormonal decline—most of which are not part of routine primary care.
Why Fasting Insulin Is the Most Critical Marker Your Doctor Misses
Fasting insulin is a leading early indicator of metabolic dysfunction, yet most doctors do not order it. Dr Comite insists it is essential for detecting insulin resistance long before blood glucose rises.
Free Testosterone Is Vital for Both Men and Women
Dr Comite explains that free testosterone affects muscle mass, memory, bone density, blood sugar regulation, and heart health in both sexes, and that optimising it has been transformative for many patients.
How Continuous Glucose Monitors Reveal Your Unique Food Response
Continuous glucose monitors (CGMs) show that two people can eat identical meals and have completely different blood sugar responses, proving that generic dietary advice is insufficient.

Editorial

The Flaw in Western Medicine: Treating Disease Instead of Creating Health
Dr Comite criticises a medical system that waits for illness to arrive rather than actively building health, leaving patients uninformed about their true risk until it is too late.

References

Invincible: Defy Your Genetic Destiny to Live Better LongerDr Florence ComiteThe episode centres on the book's message that decline is detectable and reversible.
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