The Peter Attia Drive

Peter Attia examines the failure of current prostate cancer screening guidelines, linking the decline in PSA testing to a rise in advanced and metastatic diagnoses. He explains how tracking PSA trends over time, combined with modern tools like MRI, PSA density, and improved biopsy techniques, can reduce unnecessary procedures while catching aggressive cancers earlier. The episode also covers active surveillance for low-risk cases and critiques the flawed PLCO trial that fueled anti-screening guidelines. Attia makes the case that regular, thoughtful PSA screening is essential to eliminating prostate cancer mortality.