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The Proof · October 19, 2026 · 48m

The Keto Study That Wasn't About Keto | Dr Nicola Guess

Dr Nicola Guess returns to The Proof to unpack a recent controlled feeding trial that reported a 67% reduction in liver fat on a diet labelled ketogenic. She argues that the headline masks a more important story: ketone levels in that arm were lower than expected on a true keto diet, and the higher protein intake—rather than carbohydrate restriction—may be the real driver of liver fat loss. The conversation also touches on why ApoB fell on a 23% saturated fat diet during weight loss, whether liver fat causes insulin resistance or merely marks it, and practical protein targets for building a supportive plate.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Preview

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Protein, not ketosis, may drive liver fat reduction in a ‘keto’ study
Dr Nicola Guess argues that a diet labeled ketogenic reduced liver fat by 67% not because of ketosis, but because it contained more protein — ketone levels were lower than expected for a true ketogenic diet.
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Saturated fat arm saw ApoB drop – context matters
In the same trial, participants consuming 23% of calories as saturated fat still experienced a fall in ApoB, challenging the simple narrative that saturated fat always raises cardiovascular risk markers.

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