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Sleep Unplugged · August 24, 2026 · 43m

#218 - Medication Deprescribing: Get Off This

Dr. Chris Winter explores deprescribing — the clinical movement around when and how to stop medications — and examines why some 'forever drugs' like blood pressure medication are culturally accepted while others, such as antidepressants and GLP-1 agonists, are moralized and stigmatized. He contrasts the evidence on antidepressant tapering, GLP-1 safety data, and the RLS story where dopamine agonists were downgraded by 2025 AASM guidelines due to drug-induced worsening of symptoms. The episode also notes the quiet cultural acceptance of hypersomnia medications as a revealing exception, and questions what actually determines whether long-term medication is seen as managing chronic disease or a personal failing.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Preview

The Cultural Double Standard Around 'Forever Drugs'
Blood pressure medication taken for life is accepted without question, but saying the same about an antidepressant or a GLP-1 agonist triggers moral judgment and stigma.
GLP-1 Stigma Contradicted by 2024 Safety Data
Two 2024 JAMA Internal Medicine studies found no elevated risk of depression or suicidality with GLP-1 agonists, yet the public discourse continues to treat these medications as morally suspect.

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