#215 - Seqoquel and Insomnia: Same Thing From The Same Old Cause

This solo episode of Sleep Unplugged examines how Seroquel (quetiapine), an antipsychotic, became one of the most prescribed off-label sleep aids—used in roughly ten million prescriptions a year, mostly not for psychosis. The host argues that the evidence supporting its use for insomnia is surprisingly thin, and that Seroquel is part of a larger pattern of medications repurposed for sleep based on sedation rather than rigorous trials. The show sets out to trace the drug's history and unpack how this practice took hold despite weak data.