#404 ‒ Mental health beyond neurotransmitters: the role of hormones in psychiatry, why symptom reduction isn't enough, and the future of psychedelic therapies | Linus Abrams, M.D.

Peter Attia sits down with psychiatrist Dr. Linus Abrams to explore a holistic approach to mental health that goes beyond neurotransmitters. They discuss how hormones, metabolism, inflammation, and lifestyle factors shape mood and cognition. Key topics include distinguishing bipolar from unipolar depression, the evolutionary basis of depression and insomnia, the role of estrogen and progesterone in mood, thyroid dysfunction as a mimic of depression, and the promise and perils of ketamine and psychedelics. The conversation emphasizes integrating whole-body physiology into psychiatric care to move beyond mere symptom reduction.