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The Peter Attia Drive #375 · December 8, 2025 · 180m
Ketogenic diet, ketosis, and metabolic therapies for Alzheimer's, cancer, and more
Dom D'Agostino on therapeutic ketosis for neurodegeneration and cancer. Ketones as an alternative brain fuel when glucose metabolism fails — the metabolic theory of Alzheimer's. Exogenous ketones, hyperbaric oxygen, and the military applications.
This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.
Canon
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D'Agostino: Alzheimer's brains show dramatically reduced glucose uptake (up to 45% decline). But ketone uptake remains intact. Providing ketones — through diet or supplements — gives the brain fuel it can actually use.
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D'Agostino: therapeutic ketosis increases GABA (calming neurotransmitter) and decreases glutamate (excitatory). This is the same mechanism as anti-seizure drugs — but achieved through diet instead of pharmacology.
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