“Age Reversal Is Coming.” Inside The First Human Trials - Dr David Sinclair

Dr. David Sinclair discusses the frontier of age-reversal science, including a first-of-its-kind human trial to reverse blindness using cellular reprogramming. The conversation covers the biology of aging as a treatable disease, why Sinclair believes scientists are closer than ever to radical life extension, and the lifestyle interventions he personally prioritizes—from fasting and specific exercise protocols to reframing the debate around protein intake and longevity. The episode also examines controversial longevity drugs like metformin and NAD boosters, explores the potential of GLP-1 agonists to protect against dementia, and unpacks the psychological impact of believing you can influence your own aging trajectory.