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Huberman Lab · October 5, 2026 · 2h 15m

Bringing Extinct Species Back to Life | Dr. Beth Shapiro

Dr. Beth Shapiro, evolutionary biologist and Chief Science Officer at Colossal Biosciences, joins Andrew Huberman to discuss de-extinction, ancient DNA, and synthetic biology. The conversation explores how Neanderthal genes continue to affect modern human traits, the scientific efforts to bring back woolly mammoths, dodo birds, and dire wolves, and the ethical implications of rewilding extinct species. Shapiro also explains how these same genetic tools are being used to help endangered species today, and addresses public concerns about rapidly advancing biotechnologies.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Preview

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Neanderthal DNA influences modern human immunity and traits00:30:17
Dr. Shapiro explains that many people carry Neanderthal DNA, which influences traits like immunity, red hair, and eye color, due to ancient interbreeding.
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De-extinction leverages ancient DNA and modern embryology00:30:17
Colossal Biosciences is using ancient DNA sequencing and embryology to attempt to bring back species like the woolly mammoth, dodo, and dire wolf.

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