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Huberman Lab · September 7, 2026 · 2h 3m

How Mitochondria Control Your Metabolism | Dr. Jared Rutter

Jared Rutter explains how mitochondria, the energy factories of cells, also serve as master regulators of cell growth, replication, and metabolic decisions. He discusses the fundamental role of mitochondria in aging, cancer, and metabolic diseases, and how metabolism is the sum of trillions of individual cellular decisions. The conversation covers how cells choose between energy production and growth, the discovery of key mitochondrial pyruvate carriers, and the Warburg effect in cancer.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Preview

Mitochondria as Decision-Makers: Energy vs. Growth00:36:41
Rutter reveals that mitochondria act as crucial decision points, forcing cells to choose between using resources for energy production or for growth and replication.
The Decades-Long Hunt for the Mitochondrial Pyruvate Carrier00:51:44
Rutter shares the story of how his lab finally identified MPC1 and MPC2, the elusive proteins that transport pyruvate into mitochondria, solving a mystery that had puzzled biochemists for over 50 years.

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