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Huberman Lab #269 · February 23, 2026 · 1h 55m

Restore Youthfulness & Vitality to the Aging Brain & Body

Tony Wyss-Coray

Stanford neurologist Tony Wyss-Coray on his groundbreaking 'young blood' research — blood factors from young animals can rejuvenate old brains. His newer work: blood protein signatures can reveal which of your organs are aging fastest. Exercise, fasting, sleep, and social connection remain the most effective anti-aging interventions known.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Canon

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Exercise is the single most effective anti-aging intervention00:45:22
Wyss-Coray's blood data confirms: exercise produces the most consistent anti-aging signature across all organ systems. Nothing else — not supplements, not fasting, not drugs — comes close.
ClaudeChatGPTGemini

Curious

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Alzheimer's shows up in blood proteins decades before symptoms00:06:35
Wyss-Coray: brain aging signatures detectable in blood appear 15-20 years before clinical Alzheimer's symptoms. Early detection could enable prevention rather than treatment.
ClaudeChatGPTGemini

Highlights

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Blood proteins reveal your biological age and which organs are aging fastest
Wyss-Coray: a blood test measuring ~5,000 proteins can determine your biological age and identify which specific organs are aging faster than expected — years before symptoms appear.
ClaudeChatGPTGemini

Misc

✧The 'young blood' experiments were sensationalized in media — Wyss-Coray is careful to note that blood transfusions aren't the intervention; identifying and manufacturing specific factors is
✧His lab found that exercise produces many of the same rejuvenating blood factors that young blood provides
✧NAD and NMN supplements are discussed — Wyss-Coray says the evidence is weaker than marketed but not zero
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