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Huberman Lab #232 · February 24, 2025 · 2h 20m

How to Enhance Your Immune System

Pulmonary physician Roger Seheult on evidence-based immune system optimization. The big four: sunlight exposure, exercise, sleep, and nasal breathing. Each independently strengthens immune function; together they're synergistic.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Canon

Seheult: moderate exercise (150 minutes/week) reduces infection risk by 40-50%. The mechanism: exercise mobilizes immune cells, improves circulation, reduces chronic inflammation, and enhances vaccine responses.

Curious

Seheult: nasal breathing filters, warms, and humidifies air. It also produces nitric oxide, which kills pathogens and dilates airways. Mouth breathing bypasses all of these defenses and is associated with worse immune outcomes.
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