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The Genius Life · December 3, 2025 · 59m
Why Fat Loss Gets Harder During Perimenopause
Mariza Snyder on the hormonal and metabolic shifts during perimenopause that make fat loss resistant to conventional approaches. Why calorie restriction backfires, the role of progesterone decline, and targeted interventions for women over 40.
This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.
Canon
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Snyder presents data showing that women with higher body burdens of endocrine-disrupting chemicals experience earlier and more severe perimenopause symptoms, compounding the natural hormonal decline.
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Snyder explains the estrobolome — the subset of gut bacteria that metabolizes estrogen — and how microbiome disruption leads to either estrogen excess or deficiency, worsening perimenopause.
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