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Feel Better, Live More with Dr Rangan Chatterjee · April 14, 2026 · 2h 3m

How To Support Your Immunity, Reduce Inflammation & Age Better with Dr Jenna Macciochi

Dr Jenna Macciochi
Show Notes

Dr Jenna Macciochi, a leading UK immunologist, reframes immunity as your body's master wellness system—not just a defense against colds. She explores how chronic stress, relationships, and daily habits send signals to your immune system, why midlife is a biological turning point where protective genes shift against you, and practical strategies from her own transformation (meditation, self-compassion, jiu-jitsu) that rewired her nervous system. The conversation challenges the obsession with lifespan in favor of what she calls 'soulspan'—the quality of years lived.

This summary was generated from show notes and public descriptions, not from a full transcript review. Details may contain inaccuracies.

Curious

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Midlife as Biological Turning Point
Midlife represents a genuine biological inflection point where genes that protected you in the first half of life begin working against you, affecting gut health, bone density, and long-term wellbeing.
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Highlights

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Immunity as Master Wellness System
The immune system is not primarily a defense mechanism against infection but your body's master wellness system that influences mood, metabolism, heart disease risk, dementia risk, and cancer risk.
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Chronic Stress and Inflammation Link
Chronic stress creates a direct, measurable link to chronic inflammation, which accelerates aging and drives disease risk.
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Editorial

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Immune Boosting Misconception
The popular concept of 'boosting' your immune system is misleading and potentially counterproductive if done constantly.
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Nervous System Rewiring Through Embodied Practices
Meditation, self-compassion practices, and physical practices like jiu-jitsu can rewire your nervous system and shift immune signaling.
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Soulspan Over Lifespan
The current obsession with extending lifespan misses something more fundamental: the quality and meaning of the years you live ('soulspan').
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References

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Immune to Age: The Game-Changing Science of Lifetime Health — Dr Jenna Macciochi (2026) — Latest book exploring the deep connection between immune system, lifestyle, and aging

Misc

✧Jenna left a 'misaligned marriage and job' as part of her personal transformation documented in the book
✧She discovered jiu-jitsu as part of rewiring her nervous system alongside meditation
✧Coined the term 'soulspan'—a counterpoint to the obsession with extending lifespan
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