What We Got Wrong About the Gut Microbiome (And What's Actually Right)

Dr. Mark Hyman talks with gastroenterologist and neuroscientist Dr. Emeran Mayer about the evolving science of the gut-brain connection. They discuss how the microbiome communicates with the brain, immune system, and hormones, and why a holistic approach—one that accounts for sleep, stress, exercise, relationships, and purpose—matters as much as diet. The conversation also covers the limits of probiotics and microbiome testing, the concept of a mismatch between modern lifestyles and our microbes, and the dietary patterns that support a healthier, more resilient gut.